Cyclosporine: Instructions for Use, Side Effects, and Warnings

Cyclosporine suppresses the immune system, helping your body avoid rejection of transplanted organs such as the kidneys. Rejection of a transplanted organ occurs when your body sees the transplanted organ and attacks it. And it is used after kidney, liver, or heart transplantations, to prevent rejection of these organs. It is also used to treat psoriasis or acute rheumatoid arthritis and has other uses listed in this medication guide.

    Scientific Name: Cyclosporine

    Trade name: Gengraf

 Dosage forms:

•     Solution for injection: 50 mg / ml.
•     Oral liquid preparation or oral solution: 100 mg / ml.
•     Adjustable Oral Capsules: 25.50.100 mg.

important information:

You may not be ready to use ciclosporin if you have specific medical states, use certain medications, or are receiving light or radiotherapy. Make sure your health care providers know that you are using this medicine, and talk with them about the risks and benefits of using the medicine, as it may increase your risk of cancer or serious infections, or the failure of an organ transplant.

Before taking this medicine:

Do not use cyclosporine if you are allergic to it.

You may not be able to use the medicine if you have:

•     Kidney disease.
•     Untreated or uncontrolled high blood pressure.
•     Precancerous injury.

Avoid radiation or ultraviolet light therapy, coal tar, and drugs that weaken your immune system such as methotrexate.

Ciclosporin: Instructions for use, side effects, and warnings - a medicine used after transplantation to reduce the chance of rejection by the body

Cyclosporine affects your immune system and may cause random reproduction of a type of white blood cell, which may lead to cancer or a viral infection that leads to kidney transplant failure or severe defensive infections that lead to paralysis or death.

Inform your doctor if you have liver or kidney injury, high blood pressure, or if you are planning to receive a vaccine.

We do not know the danger of the medicine on the unborn fetus, so the patient must inform the doctor about pregnancy or planning a pregnancy, and children should stop breastfeeding while they are using the medicine.

How to use the medicine:

Read the medication guide instructions and follow all the directions in the prescription guide. Your doctor may accidentally change the prescribed dose, so stick to the medication as prescribed.

The medication is given as an infusion by a healthcare provider if you are not able to take it orally. He will monitor your condition for about thirty minutes after the injection, to make sure that there is no allergic reaction to it.

The medicine can be taken with or without food, but one of the two methods must adhere to each time and at the same time every day.

Adjust the dose of the liquid preparation carefully, and ensure that the dosing injector is dry before using it to adjust the dose. The oral solution of the medication may be mixed with milk or orange juice to improve its taste. The neutralizing solution (emulsion) should be mixed with orange or apple juice at room temperature.

The dose may need to be adjusted if the commercial medicine product, strength (dose), or form has changed.

Avoid being mistaken in your compliance with the formula/form and dosage prescribed by your doctor, and do not alter the dosage or treatment plan without medical advice. You will need to undergo regular medical examinations, and you will be under medical care while you use the medicine.

Store the medicine at room temperature apart from heat and moisture.

How to do if you miss a dose?

Take the medicine as soon as you remember the dose unless it is almost time for the next dose, then skip the missed dose. Do not take a double dose to make up for what you missed.

How to behave if you take an overdose?

Seek immediate medical care.

What to avoid during treatment with cyclosporine:

• Avoid eating products that contain grapefruit. The follicle may interact with ciclosporin, causing side effects that are not desirable. Avoid alcohol, stay away from sick and infected people, and inform the doctor if you experience symptoms of infection.
• During your treatment, do not receive a live vaccine against the following: measles, mumps, rubella, typhoid, yellow fever, polio, varicella, herpes, rotavirus, the vaccine may not be effective and it does not protect you from diseases completely.

Side effects of the drug:

• Seek immediate medical care if you experience the following symptoms of an allergic reaction: (urticaria, shortness of breath, swelling or swelling of the face, lips, tongue, and throat).

Tell your doctor if you experience:

•     The trouble with speech, thinking, vision or physical movement may start gradually and get worse quickly.
•     Convulsive seizures.
•     Severe headache, blurred vision, and ringing in the ears.
•    Pale skin, and unusual bleeding.
•     A feeling of nausea, and high blood potassium.
•     Feeling weak, chest pain, and an irregular heartbeat.
•     Renal problems: decreased or no urination, swelling or edema of the foot or ankle, fatigue, and shortness of breath.
•     Liver problems: stomach pain, loss of appetite, yellowing of the skin and eyes, or jaundice.
•     Symptoms of infection or fever: chills, cough, trouble breathing, runny and sore throat, and skin ulcers.

Common side effects may include:

1.     Tremors and tremors.
2.     Pimples or acne, excessive growth of body, and facial hair.
3.     Nausea and diarrhea.
4.     Swelling, swelling, and pain in the gums.

The previous effects list is not complete, and others may appear.

Some side effects do not require immediate medical attention, and these effects disappear during treatment as your body adjusts to the medication. Your medical care provider may tell you about methods to follow to prevent or reduce some of these effects, including:

Abdominal or stomach discomfort, excessive hair growth, especially on the face, pain around the eyes and cheeks, runny nose, and pimples.

Medicines that affect cyclosporine and interfere with it:

Sometimes it is not a good idea to use specific medicines at the same time. Some medicines may affect the blood concentrations of the other medicines you are taking with them, which may increase the side effects of the medicine or make it less effective. Cyclosporine can harm your kidneys, especially if you are taking specific medicines to treat infections, cancer, osteoporosis, rejection of transplanted organs, intestinal disorders or arthritis, or for pain relief such as aspirin, Tylenol, Advil, and Aleve.

Many drugs may interact with cyclosporine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here, so tell your doctor about all medications that you are taking or have stopped using.